Activatable Nanovesicle Rewires Immunometabolic Barriers for NIR-II Photoacoustic-Guided Sono-immunotherapy of Glioblastoma
Glioblastoma (GBM) remains largely refractory to immunotherapy owing to a restrictive brain tumor niche that limits therapeutic access and fosters persistent immune evasion. Here, we present a programmed nanovesicle to sequentially overcome biological barriers and rewire the immune landscape of GBM. The system integr...