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Author

Yuanfeng Lan

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Oct 2026

PDZ domain containing 1 sensitizes renal cancer cells to everolimus via inhibiting phosphatase and tensin homolog phosphorylation-mediated mTOR pathway activation.

Aberrant activation of the phosphatase and tensin homolog (PTEN)-PI3K/AKT/mTOR pathway is a key driver of renal cell carcinoma (RCC) progression, making mTOR inhibition with everolimus a critical therapeutic strategy. However, the mechanisms driving mTOR pathway activation and the emergence of drug resistance remain po...

Yi-Nong Niu, Zhi-Yu Fang, Lei Wang et al. · 0 citations
Open access Jul 2026

Multi-Omic Analysis of Cerebrospinal Fluid Metabolites in Autism Spectrum Disorder: Biomarker Identification, Metabolic Genetics Insights, and Network Toxicology

This study provides suggestive evidence that elevated adenine and proline may be potential risk factors for ASD and suggests possible involvement of the mitochondrial–Hippo–microtubule pathway, and proposes benzo[a]pyrene as a candidate environmental toxicant that may perturb CSF metabolism.

Dan Zhao, Jun-Zhi Guo, Ying Zhang et al. · 0 citations

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