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Yuanyuan Wu

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Jul 2026

Discovery of natural product-derived rosavin as a programmed death-ligand 1 inhibitor for cancer immunotherapy.

Rosavin is identified as a privileged novel and unexpected scaffold for designing potent PD-1/PD-L1 modulators, offering promising candidates for cancer immunotherapy and exhibiting the unusual small-molecule property of inhibiting PD-L1 without inducing its dimerization.

Wei Zou, Tianle Li, Jacek Plewka et al. · 0 citations