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Author

Yubin Luo

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Review Open access Sep 2026

ALKBH5 inhibitors for cancer therapy: molecular docking, challenges and future prospects

N6-Methyladenosine (m6A), the most abundant internal modification of eukaryotic mRNA, is dynamically reversed by the FeII/α-ketoglutarate-dependent dioxygenase ALKBH5, a key m6A “eraser” that regulates target mRNA fate through demethylation. ALKBH5 is aberrantly overexpressed in acute myeloid leukemia, glioblastoma, br...

Chen Deng, Hai Xu, Jian Pu et al. · 0 citations
Jul 2026

Repurposing simeprevir uncovers a druggable KPNB1-p65-BCL2 survival axis in cancer.

This study elucidates a therapeutically targetable KPNB1-p65-Bcl-2 survival axis in multiple cancers and establishes a foundation for developing next-generation KPNB1 inhibitors.

Cong Li, Qiaohua Yan, Muhammad Muddasar Saeed et al. · 0 citations

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