Yudisthira Oktaviandie

Charge-driven remodelling of monomeric Tau determines its phase behaviour

Tau transitions from a functional microtubule-stabilising monomer into pathological aggregates in tauopathies. However, the molecular mechanism by which soluble Tau transitions into insoluble aggregates remains poorly understood. Here, we show that modulation of Tau’s internal charge-charge interactions by pH and ionic...