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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Yue-Chan Wang

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Open access Sep 2026

Sirt1 attenuates calcific aortic valve disease by inhibiting ferroptosis and enhancing mitochondrial function via the activation of the Nrf2/HO-1/FTH1 axis

Calcific aortic valve disease (CAVD) is a progressive disorder characterized by valvular calcification and currently lacks effective pharmacological therapies. Sirtuin 1 (Sirt1) has emerged as a cardioprotective factor; however, its role in CAVD remains unclear. The present study aimed to investigate whether Sirt1 atte...

Fei Yan, Lei Shi, Yue-Chan Wang et al. · 0 citations

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