Neurodegenerative diseases (NDs) are chronic neurological diseases characterized by progressive neuronal loss and pathological protein deposition in specific brain regions. With the deepening of population aging, these diseases have become one of the most serious public health challenges. Due to the high heterogeneity...
Yi Li, Ke Pu, De-Qiang Li et al.· Ageing Research Reviews· 0 citations
Poly(ADP-ribose) polymerase (PARP) is highly expressed in various malignancies and represents an important therapeutic target. Noninvasive evaluation of PARP expression is therefore of potential clinical significance for patient stratification. In this study, we developed and evaluated [68Ga]Ga-DOTA-MK-4827, a structur...
Jia Deng, Die You, Chun-Fang Zhang et al.· ACS Omega· 0 citations
Fibroblast activation protein (FAP) is an attractive target for cancer theranostics; however, currently available FAP-targeted radiopharmaceuticals often exhibit rapid clearance and insufficient tumor retention. In this study, we designed two covalently modified FAP-targeted radiotracers, [68Ga]Ga-T1 and [68Ga]Ga-T2,...
Jia Deng, Chun-Fang Zhang, Die You et al.· Molecular Pharmaceutics· 0 citations
Background Thyroglobulin (Tg) is a standard biomarker for monitoring differentiated thyroid carcinoma (DTC) after radioiodine therapy, yet its reliability is compromised by false-positive and false-negative results. This study aimed to evaluate the diagnostic performance of 68Ga-FAPI-04 PET/CT, an emerging imaging moda...
