Author

Yue Cheng

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#diffusion models Open access Sep 2026

scLDM: a conditional diffusion framework for single-cell perturbation prediction.

MOTIVATION Accurate prediction of single-cell responses to external stimuli is pivotal for deciphering gene regulatory mechanisms and accelerating data-driven drug discovery. However, effectively capturing the complex, non-linear mapping between intrinsic cell states and external stimuli remains an open problem. RESU...

Bo-Yang Wu, Yu-Hang Liu, Yue Cheng et al. · Bioinformatics · 0 citations

Open access Sep 2026

DECANT: decoupling mechanism from context in single-cell drug perturbation representation

Abstract Motivation Single-cell chemical perturbation profiling offers a powerful opportunity to organize drugs by shared mechanism-associated transcriptional responses, but observed transcriptional responses are entangled with contextual variation from cell identity, dose, and treatment time. As a result, models that...

Ren Qi, Wen-Jie Teng, Xin Yang et al. · Bioinformatics · 0 citations