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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yue Gao

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2 papers indexed here

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Sep 2026

Discovery and characterization of PGC-01: An effective GSDMD-targeting PROTAC.

As the key executioner protein of pyroptosis, GSDMD represents a promising yet underexplored therapeutic target for inflammatory diseases. In this study, we explored a PROTAC-based degradation approach targeting GSDMD for the treatment of pyroptosis-driven inflammatory conditions. Through screening of our in-house comp...

Qian-Qian Wang, Rong-Ying Hou, Yi-xuan Shua et al. · 0 citations
Open access Sep 2026

Integrated Transcriptomic and Proteomic Analysis Elucidates the Mechanisms of Huperzine A Injection Against Cerebral Ischemia/Reperfusion Injury

Background After recanalization in acute ischemic stroke, cerebral ischemia/reperfusion injury (CI/RI) drives a cascade of pathophysiological events that worsen clinical outcomes, yet effective therapeutic options remain limited. Given the neuroprotective potential of Huperzine A (HupA), the efficacy of HupA injection...

Yu-Le Wang, Lin-Yun Xie, Yue Gao · 0 citations

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