Yue He

Dual metabolic checkpoint blockade via a 3D-Printed metalloplatform remodels the tumor ecosystem for systemic antitumor immunity

The immunosuppressive tumor microenvironment limits the efficacy of therapies that target metabolism. Here we show a strategy of dual metabolic regulation that simultaneously reprogramming glycolysis in cancer cells and fructose metabolism in tumor-associated macrophages, transforms the metabolic ecosystem from pro-tum...