Open access
Sep 2026
The α-helix-facilitating amino acid sequence EAAAK dramatically increases the antiviral activity of SARS-CoV-2 fusion-inhibitory peptides via the endosome fusion pathway
It is demonstrated that the C-terminal EAAAK motif in IPB29—originally designed as a rigid linker connecting the peptide backbone to the lipid moiety—is critical for its antiviral activity and functions via the endosomal fusion pathway.
Zhi-Xin Yao, Yuan-Mei Zhu, Nian Liu et al.
· Journal of Virology · 0 citations