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Review Open access Sep 2026

Druggable tumor-nerve-immune circuits in cancer pain: model systems, human translatability and therapeutic paradoxes.

Cancer pain is increasingly recognized as an active output of tumor-nerve-immune biology rather than a passive consequence of tissue damage. Tumor-derived algogens, neurotrophic factors, stress signals and immune mediators can sensitize nociceptors, facilitate perineural invasion, remodel myeloid and lymphoid compartme...

Yue Hu, Ling-Xuan Hou, Xiao-Bei Zhang et al. · 0 citations
Review Open access Sep 2026

Efficacy of psychological interventions versus standard care for cancer pain: a systematic review and meta-analysis

Background Cancer-related pain is frequently accompanied by psychological distress, which may worsen symptom burden and impair quality of life. This systematic review and meta-analysis aimed to evaluate the efficacy of psychological interventions versus standard care for pain intensity, depressive symptoms, and anxiety...

Yue Hu, Hai-Xiao Liu, Ling-Yun Wang et al. · 0 citations

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