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Author

Yue Li

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Sep 2026

Abstract B066: Convergent cell-state programs characterize BRCA2 -reversion-independent resistance in pancreatic cancer

This work modeled resistance using patient-derived xenografts from two PDACs harboring pathogenic germline BRCA2 variants, and identified convergent transcriptional and epigenetic cell states associated with BRCA2-reversion-independent platinum/PARPi resistance in PDAC.

J. Romero, Yi-Fan Wang, Edward Shanbedi et al. · 0 citations
Open access Jul 2026

SpatialJEPA: JEPA-inspired graph-context distillation for spatially aware multiomics integration

SpatialJEPA is introduced, a JEPA-inspired teacher–student framework for transferring spatial context from spatial multiomics data to non-spatial multiome data, which masks spatial context by replacing the teacher’s spatial neighborhood graph with a self-only identity graph during student training, making the spatial s...

Dylan Mann-Krzisnik, Yue Li · 0 citations

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