Case report end-stage cystic fibrosis with fatal outcome in two siblings from a Chinese family: a 15-year diagnostic odyssey
Background Cystic fibrosis (CF) remains severely underdiagnosed in China due to the absence of newborn screening, limited sweat chloride testing capacity, and low clinical awareness. Diagnostic delay results in irreversible lung damage and precludes timely genotype-directed therapy. Case Presentation A 16-year-old Chin...