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Yue-Long Li

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Open access Sep 2026

A phage DUF669 protein mediates post-cleavage DNA repair against host CRISPR immunity

Phages have evolved various anti-CRISPR (Acr) proteins or RNA-based anti-CRISPR (Racr) to evade host CRISPR immunity by direct interference. However, whether other counter-CRISPR mechanisms exist remains unexplored. Here, we report a phage-encoded two-protein system, termed Healer, which neutralizes CRISPR immunity via...

Heng-Cha Zhu, Sheng-Kun Dai, He-Wen Deng et al. · 0 citations

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