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Author

Yue Song

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Aug 2026

Neddylation-triggered ubiquitination and proteasomal degradation of HELLS inhibits prostate cancer growth via genomic instability.

The chromatin remodeler HELLS (also known as LSH/SMARCA6) is a macromolecular regulator essential for maintaining genomic stability. Here, we identify HELLS as a critical oncogenic driver in prostate cancer and elucidate a previously unrecognized post-translational cascade that governs its protein stability. Mechanisti...

Yu Zhang, Nuorong Xiong, Boxin Du et al. · 0 citations

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