Yue-Xin Liu

Photocaging of a GPR52 agonist enables light-dependent receptor activation in cells.

GPR52 is an orphan G protein-coupled receptor implicated in neuropsychiatric disorders and has attracted interest as a small-molecule drug discovery target. Here, we report the design, synthesis, and biological evaluation of photocaged derivatives of the GPR52 agonist 7d. Among the derivatives prepared, DMNB-7d showed...