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Author

Yue Yang

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Open access Sep 2026

Exacerbation of renal interstitial fibrosis by the UHRF1/G9a axis through epigenetic silencing of KLF15

Abstract Renal fibrosis represents a central pathological driver of chronic kidney disease (CKD), yet the epigenetic mechanisms remain incompletely understood. This study identifies a critical role for the Ubiquitin-like with PHD and RING Finger domains 1 (UHRF1)/G9a axis in this process. We demonstrated that both UHRF...

Jia-Yi Wang, Yulin Wang, Shuang-Xin Yuan et al. · 0 citations
Open access Aug 2026

Causal relationships between gut microbiota, metabolites, and chronic kidney disease: a two-step, two-sample Mendelian randomization study

Genetic evidence is provided that gut microbiota influence CKD risk partially through circulating metabolites, highlighting the gut microbiota–metabolite–CKD axis as a potential therapeutic target.

Ying Qian, Yue Yang, Zi-Yan Shen et al. · 0 citations

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