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Yue-Yue Zhang

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Open access Aug 2026

Targeting Runx1 Slows Cyst Growth in Autosomal Dominant Polycystic Kidney Disease

Mechanistically, Runx1 enhances proliferation of cyst‐lining epithelial cells by activating the AKT–mTOR, MAPK, and STAT3 signaling cascades, while suppressing p53‐mediated apoptosis.

Yue-Yue Zhang, Chang Liu, Jun-Chi Liu et al. · The FASEB Journal · 0 citations