Natural variation in BtSARSr-CoV nsp12 harbors adaptive mutations that enhance viral replication and spillover risk in humans
ABSTRACT The non-structural protein 12 (nsp12) is essential for SARS-related coronavirus (SARSr-CoV) replication and a major antiviral target, yet the functional significance of its natural variation in bat reservoirs remains unclear. Here, by analyzing 183 bat SARS-related coronavirus nsp12 sequences, we identified mu...