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Yueying Yang

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Aug 2026

Discovery of DCAF16-based PROTACs as SHP2 degraders.

The design and synthesis of SHP2 PROTACs that recruit the DCAF16 E3 ligase for targeted SHP2 degradation are reported that support the potential of SHP2-targeted protein degradation as an alternative strategy to enzymatic inhibition and provide a promising starting point for the further development of SHP2 degraders.

X. Pang, Yuxin Gan, Qingyuan Hu et al. · 0 citations