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Aug 2026

Facilitation of Autophagosome-Lysosome Fusion by LAPTM4A: A Novel Strategy for Attenuating Myocardial Ischemia-Reperfusion Injury.

BACKGROUND Myocardial ischemia-reperfusion (MIR) injury compromises therapeutic effects of revascularization and leads to functional impairment and exacerbation of structural damage in the heart. Limiting the damage caused by MIR is crucial but is still an unmet clinical need because of the complexity of the underlying...

Si-Yi Zhou, Jia-Yi Liu, Man-Li Hu et al. · 0 citations
Review Jul 2026

Mitophagy in Cardiovascular Disease: From Mechanistic Insights to Therapeutic Horizons.

Cardiovascular diseases (CVDs) remain a leading cause of death worldwide, with a complex and multifactorial pathophysiology. Given its high energy demands, the heart is critically dependent on mitochondrial energy production and metabolic homeostasis. Mitophagy, a selective form of autophagy, represents a crucial intra...

Deyi Guo, Kun Wang, Jingwen Zhang et al. · 0 citations

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