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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yuhao Wei

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Aug 2026

Tumor-intrinsic PHGDH inhibition sensitizes colorectal cancer to PD-1 blockade via α-ketoglutarate-mediated macrophage reprogramming.

Metabolic reprogramming of tumor cells profoundly shapes the tumor microenvironment and contributes to immunotherapy resistance in colorectal cancer (CRC). Here, we identify phosphoglycerate dehydrogenase (PHGDH), a rate-limiting enzyme in de novo serine biosynthesis, as a metabolic regulator of antitumor immunity. In...

Jie-Ping Qiu, Jingwen Wei, Jiaming Liu et al. · 0 citations

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