Aug 2026
Mapping the covalent cysteine interactome of Ebselen reveals high-sensitivity target engagement and redox proteome remodeling.
Ebselen is a covalent organoselenium compound with broad pharmacological activity, yet its cellular cysteine targets and downstream proteomic consequences remain incompletely defined. Here, we integrated competitive gel-based activity-based protein profiling, reactivity-dependent tandem orthogonal proteolysis-activity-...
Yi-Ru Liu, Yu-Qiu Zi, Zhongyao Jiang et al.
· Bioorganic chemistry (Print) · 0 citations