TMEM16A Ca2+-activated Cl- channel: Functional interactions with cytoskeletal and membrane-associated proteins.
The calcium-activated chloride (ClCa) channel TMEM16A (also known as ANO1) is widely expressed in epithelial cells, interstitial cells of Cajal, nociceptive neurons and smooth muscle cells, where it plays essential roles in ion transport, neurotransmission and smooth muscle contraction. Dysfunction of TMEM16A channels...