Author

Yukiko Gotoh

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Open access Sep 2026

Polycomb establishes TAD-scale H3K27me3 mega-domains to safeguard neuronal identity

These findings reveal a previously unrecognized role for PRCs in establishing TAD-scale repressive chromatin domains during neuronal maturation, thereby safeguarding neuronal identity from external stimuli through broad silencing of alternative cell fate programs.

Natsumi Yamada, Chika Ichihara, Kazunori Hojo et al. · bioRxiv · 0 citations