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Author

Yuko Ono

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Open access Aug 2026

Association between empagliflozin exposure and skeletal muscle degeneration in patients with heart failure

Sodium–glucose co-transporter 2 inhibitors (SGLT2i) have become essential in the management of heart failure. Their prognostic benefits are consistent across older adults, frail, and underweight patients, but there may be potential adverse effects on the skeletal muscle. In this prospective single-centre observational...

Tatsuya Nishikawa, Nobuto Nakanishi, Kayo Osawa et al. · 0 citations
Open access Jul 2026

Adenosine 5'-monophosphate prevents sepsis-associated muscle wasting by activating AMPK and suppressing IL-1β inflammatory cytokines

It is demonstrated that AMP effectively mitigates SAMW by activating AMPK and suppressing IL-1β-mediated molecular pathways and highlighting the potential of AMP as a novel therapeutic agent for preserving skeletal muscle functionality and morphology in sepsis.

I. Yoshihara, Narumi Yoshihara, K. Hanafusa et al. · 0 citations

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