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Author

Yumi Itoh

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2 papers indexed here

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Oct 2026

Development of YO-01027-Derived Signal Peptide Peptidase Inhibitors with Reduced γ-Secretase Inhibition

Signal peptide peptidase (SPP) is an endoplasmic-reticulum intramembrane aspartyl protease required for hepatitis C virus (HCV) core protein maturation, but many SPP inhibitors also inhibit γ-secretase. Here, we designed YO-01027-derived dibenzazepinone analogs to retain SPP inhibition while reducing γ-secretase liab...

Hidetomo Yokoo, Tomomi Hishinuma, Takashi Kurohara et al. · 0 citations
Open access Sep 2026

Intracellular Zn2+ levels regulate susceptibility to hepatitis B virus infection by modulating NTCP-mediated viral entry.

Hepatitis B virus (HBV) infection remains a significant global health challenge and is a leading cause of chronic liver diseases, including cirrhosis and hepatocellular carcinoma. Although nucleos(t)ide analogs and interferon-based therapies suppress viral replication, they do not eliminate the viral reservoir, highlig...

Yumi Itoh, Chiharu Morita, Jin-Zi Cui et al. · 0 citations

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