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Author

Yun-Cheng Duan

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Open access Sep 2026

Probabilistic mapping of sub-genic intolerance reveals functional and disease-critical protein regions

Different regions of genes perform distinct functions and vary in their importance to human health. Evolutionary intolerance provides a powerful means of identifying regions where disruptive mutations are under strong purifying selection, informing genetic disease discovery and variant interpretation. However, estimati...

Constantine Stavrianidis, Yun-Cheng Duan, Grace E. Rhodes et al. · 0 citations
Aug 2026

Quantitative profiling of intrinsic dCas9-DNA recognition reveals key determinants of guide RNA performance

TANGO (Targeted Array-based Nucleic acid-Guided Occupancy), a high-density DNA-array platform that quantitatively profiles intrinsic dCas9:gRNA binding across tens of thousands of DNA targets in a cell-free system, establishes intrinsic DNA recognition as a quantitative and experimentally accessible determinant of dCas...

Wei Zhu, Michael Tian, Yuncheng Duan et al. · 0 citations

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