Yun-Gui He

Nanobody-Functionalized AAV achieves Promoter-independent Neuronal Targeting in the CNS å

Adeno-associated virus (AAV) vectors are widely used for gene delivery to the central nervous system, but natural capsid tropism is broad and cell-type restriction is typically imposed transcriptionally using promoters and enhancers that consume packaging capacity and often drive weak expression. Here, we enhance neuro...