Co-administration of a chicken interleukin-2-interferon-α fusion protein enhances immune responses and protective efficacy of an inactivated fowl adenovirus serotype 4 vaccine.
Hydropericardium syndrome (HHS) caused by fowl adenovirus serotype 4 (FAdV-4) poses a severe threat to global poultry production. Although inactivated vaccines are widely used, they may elicit suboptimal cellular immune responses and provide incomplete protection. In this study, six candidate immunostimulants were comp...