A pH‐adaptive nanozyme platform (MICP@HG) is presented that orchestrates stage‐specific antibacterial and immunomodulatory activities throughout sepsis progression and elicits a vaccine‐like trained immunity effect that confers protection against reinfection.
An-Lai Zou, Xiao-Xue Zhu, Run-Han Zhu et al.· Advancement of science· 1 citation
This review synthesizes current mechanistic and translational evidence to conceptualize the gut microbiome as an organ‐like functional system, delineate its structural and functional organization, and propose a framework for mapping, modeling, and therapeutically targeting microbiome‐derived circuits to support precisi...
Yang Bi, Wei-Bin Song, Maria Glymenaki et al.· iMeta· 0 citations
A simple and robust strategy using dibenzocyclooctyne-mediated click chemistry to modulate CRISPR-Cas12a activity and shows that DBCO-modified activators can regulate CRISPR-Cas12a cleavage in three distinct states: maintain, enhance, and suppress.
