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Molecular mechanisms of bacterial defense and phage counter-defense are summarized, coevolutionary models are discussed, ecological and applied implications are highlighted, and future research directions are outlined.
This review systematically analyzes major challenges restricting clinical application, such as standardized production, quality control, pharmacokinetic characterization, rapid pathogen identification, and regulatory adaptation, as well as the limited performance of fixed phage cocktails against genetically heterogeneo...
Dopamine was taken up by the bacteria and was associated with enhanced pathogenic phenotypes, including increased proliferation, toxin production, biofilm formation, motility, adhesion, and multidrug resistance and deletion of saeS markedly attenuated these dopamine-associated effects.
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