Beyond Agonist Delivery: Metallic Nanomaterials as Active Regulators of cGAS-STING Signaling in Cancer Immunotherapy
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway represents a pivotal innate immune signaling axis that bridges cytosolic DNA sensing with type I interferon and pro-inflammatory cytokine production. However, the clinical translation of STING agonists, particularly cyclic dinucleotides (...