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Author

Yunyun Fei

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Open access Oct 2026

Engineered receptor-biased IL-2-drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy.

Autoimmune and inflammatory diseases arise from a breakdown of immune tolerance driven by hyperactivation of effector lymphocytes and dysfunction of regulatory T (Treg) cells. Interleukin-2 (IL-2) supports both Treg maintenance and effector cell responses, necessitating careful dose optimization for selective immune re...

Jing Li, Shan-Bo Yang, Ye-Shuang Yuan et al. · 0 citations
Aug 2026

Autoimmune disease patients with comorbid cancer exhibit prominent immunometabolic crosstalk.

Together, these findings define an internally consistent immunometabolic pattern associated with cancer comorbidities in patients with AIDs and nominate amino acid metabolism and CXCL9/Galectin-9-centered immune signaling as candidates for mechanistic investigation and biomarker development, while underscoring the need...

Xu Jiang, Yangzhige He, Nai-Xin Liang et al. · 0 citations

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