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Yunfei An

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Case report Open access Sep 2026

A truncating ELF4 variant in a pediatric patient with autoinflammatory disease and cell type-specific immune alterations

Introduction ELF4 is an ETS family transcription factor involved in immune regulation, including antiviral responses and inflammatory signaling. Germline loss-of-function variants in ELF4 cause deficiency in ELF4, X-linked (DEX), a disorder characterized by recurrent mucocutaneous inflammation and variable immune abnor...

Qian-Lu Zhang, Ya-Tang Lei, Li-Na Zhou et al. · 0 citations
Review Jul 2026

Artificial intelligence (AI) as a catalyst for mechanistic target discovery: Integrating systems pharmacology and multimodal data.

It is demonstrated that this AI-driven paradigm is essential for advancing precision medicine, as it systematically translates vast and heterogeneous datasets into testable mechanistic hypotheses, and accelerates the development of safer, more effective and patient-specific therapies.

Xuerui Song, Zhi Chen, Yunfei An et al. · 0 citations

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