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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Yunfeng Yu

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Open access Aug 2026

Histone lactylation encodes innate immune memory in atherosclerosis: a hypothesis of epigenetic bookmarking for residual inflammatory risk

Histone lactylation, particularly H3K18 lactylation (H3K18la), has emerged as a lactate-derived epigenetic modification that links metabolic reprogramming to sustained chromatin states. Here, we advance a hypothesis that the lactate-p300-H3K18la axis functions as an epigenetic memory code, converting transient glycol...

Hao-Bo Yang, Yonghui Zhang, Yunfeng Yu et al. · 0 citations

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