Review
Open access
Aug 2026
Role of pks + Escherichia coli in colorectal cancer: Mechanisms, clinical evidence, and therapeutic perspective.
Colorectal cancer (CRC) is a multifactorial disease influenced by genetic, environmental, and microbial factors. Among gut microbiota, pks+Escherichia coli has emerged as a key contributor to colorectal carcinogenesis through the production of colibactin, a genotoxic secondary metabolite. Colibactin induces DNA damage...
Sina Nasrollahian, M. Halaji, Parisa Honarvar Bakeshloo et al.
· Infection, Genetics and Evol... · 0 citations