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Author

Yuning Yang

2 papers indexed here

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Open access Aug 2026

A Tumor-Microenvironment-Responsive Chemically Masked IL‑2 Prodrug Potentiates PD‑1 Checkpoint Blockade and Elicits Robust Antitumor Efficacy

Interleukin-2 (IL-2) is a potent mediator of T-cell activation with significant potential for cancer immunotherapy, yet its clinical utility is severely constrained by its narrow therapeutic window. Here we report a chemically masked IL-2 prodrug (Cm-proIL2) that enables tumor-microenvironment-responsive cytokine activ...

Linzhi Tan, Yuning Yang, Ke-Rui Zhao et al. · 0 citations
Review Aug 2026

Pyroptosis‐Inducing Nanomedicine for Cancer Immunotherapy: Mechanisms and Emerging Strategies

Cancer immunotherapy has revolutionized oncologic treatment, yet its efficacy remains constrained by tumor immune evasion and the immunosuppressive tumor microenvironment. Addressing these multifaceted barriers calls for strategies that can both eliminate cancer cells and simultaneously amplify antitumor immunity. Pyro...

Pengfei Wang, Xinxin Sun, Yuning Yang et al. · 0 citations

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