Author

Yunn-Hwen Gan

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Open access Sep 2026

Different gut microbiome dysbioses impact the evolutionary fate of hypervirulent Klebsiella pneumoniae

Abstract The intestinal microbiota acts as a barrier against pathogen colonization, yet how specific ecological perturbations shape the evolutionary fate of invading pathogens remains unclear. Here, we show that the mode of gut perturbation and type of dysbiosis determine whether hypervirulent Klebsiella pneumoniae (hv...

Carey Lim, Jia-Ling Zheng, Guoxiang Cheam et al. · iMeta · 0 citations

Jul 2026

A Dictyostelium discoideum Cell-Based Biosensor Reveals Capsule-Associated Virulence Phenotypes in Hypervirulent Klebsiella pneumoniae.

A proof-of-concept cell-based biosensing framework using the social amoeba Dictyostelium discoideum to detect capsule-associated virulence phenotypes in the model hvKp strain SGH10 is established, showing that loss of capsule production strongly reduces mucoviscosity, zebrafish lethality, resistance to amoebal predatio...

Ian Pérez-Ramírez, Matías Gálvez-Silva, Diego Rojas et al. · ACS Sensors · 0 citations