Mitochondrial Reverse Electron Transfer Contributes to Oxidative Damage in Sepsis-Induced Cardiomyopathy.
Sepsis-induced cardiomyopathy (SICM) is a severe complication of sepsis characterized by myocardial depression and high mortality, yet the underlying mechanisms remain incompletely understood. Here, we provide evidence supporting reverse electron transfer (RET) at mitochondrial complex I as a contributing pathogenic me...