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Yuntao Qian

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Preprint Jul 2026

An Hybrid Quantum-Classical Diffusion Model for Image Generation

Quantum diffusion models provide a physics-consistent route to generative learning by formulating noising and denoising directly on quantum states. However, applying such models to classical high-dimensional data is constrained by the qubit cost of state encoding and the computational burden of simulating large density operators. We propose a scalable hybrid generative pipeline that combines a classical autoencoder for dimensionality reduction with a mixed-state quantum denoising diffusion probabilistic model (MSQuDDPM) operating in the learned latent space. The autoencoder compresses data into compact latent codes that can be embedded into a small-qubit Hilbert space, after which the quantum diffusion model learns a generative distribution over latent density operators and decodes samples back to the original domain. Algorithmically, we simplify the reverse dynamics by predicting an estimate of the clean state $\rho_0$ at timestep $t$ and computing the one-step reverse update via an analytic backward propagation rule, rather than learning an explicit predictor for $\rho_{t-1}$. We demonstrate the proposed approach on MNIST image generation and discuss how mixed-state quantum diffusion can serve as a practical backbone for hybrid quantum--classical generative modeling under realistic qubit budgets.

Qipeng Qian, Keli Deng, Yuntao Qian · 0 citations
Review Jun 2026

Facilitating structure-based drug discovery with an artificial intelligence-driven virtual screening platform.

The Comprehensive VS Platform with AI Engine (CVSP-AIE) for drug discovery from compound libraries integrates three AI models: KarmaDock, a fast docking model that directly updates atomic coordinates; CarsiDock, an accurate docking model that predicts protein-ligand distances and reconstructs binding poses; and RTMScore, an accurate scoring model that learns residue-atom distance distributions for affinity prediction.

Shu-kai Gu, Xujun Zhang, Mengwu Xiao et al. · 1 citation