Review
Open access
Oct 2026
Cancer-associated fibroblasts as key mediators of therapeutic resistance and tumor progression in colorectal cancer
Cancer-associated fibroblasts (CAFs) are instrumental in tumor progression by interacting with tumor cells, other stromal components, and the extracellular matrix (ECM) within the tumor stroma. The origin, heterogeneity, and activation mechanisms of CAFs in different cancer types have been widely reported....
Bárbara Martins de Lima Coelho, L. B. Murad, Renata Machado Brandão Costa et al.
· Cancer Cell International · 0 citations