Author

Yutaka Matsuda

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Open access Oct 2026

Organic Cosolvent-Free Antibody–Drug Conjugation Enabled by Hydrophilic Linker–Payloads

Bioconjugation of linker–payloads (LPs) to antibodies has historically relied on organic cosolvents or surfactants to overcome the poor aqueous solubility of cytotoxic payloads─an assumption that has remained largely unquestioned in antibody–drug conjugate (ADC) manufacturing. Here, we systematically re-evaluate this...

Yutaka Matsuda, Heng-Qin Cheng, John Hartung et al. · ACS Omega · 0 citations

Open access Jul 2026

LC-MS/MS Quantification and Solvent-Exposure Modeling Reveal a Mismatch Between Linker Exposure and Payload Release in Wild-Type Trastuzumab-VC-PABC-MMAE in Rat Plasma.

A mismatch between modeled exposure and observed release argues against a simple exposure-driven cleavage mechanism as the primary explanation for the wild-type behavior and suggests that the observed payload release is influenced by bond chemistry in addition to linker exposure.

Kazutoshi Takahashi, Shunsuke Yamazaki, Yutaka Matsuda · Biomedical chromotography · 0 citations