Aug 2026
Asiaticoside attenuates endothelial cells senescence in diabetic retinopathy via CCND1-mediated mitophagy through the PI3K/AKT/mTOR pathway.
This study is the first to explore the pathological role of CCND1 in DR beyond its classical cell-cycle regulatory function, and reveals that AC attenuates DR progression by alleviating cellular senescence in HMECs by modulating CCND1.
Zhouyang Chen, Yuxin Luo, Xueying Lou et al.
· Journal of Ethnopharmacology · 0 citations