Gi-DREADD-mediated modulation of astrocyte in the dorsal hippocampus improves working and hippocampus-dependent memory in the unilateral 6-hydroxydopamine lesioned rats.
Cognitive impairment deficits is one of the common non-motor symptoms of Parkinson's disease (PD). Although the mechanism is still unclear, emerging research suggests that the dorsal hippocampus (dHIPP) and astrocyte (AS) may be involved in the cognitive dysfunction in PD. Thus, the effects of Gq or Gi mediated designe...