Review
Open access
Aug 2026
Pyroptosis and HMGB1 Signaling in T2DM-Related Sarcopenia: Current Evidence, Mechanistic Framework, and Exercise Implications
Current evidence for inflammasome- and gasdermin-related pyroptotic signaling, HMGB1-associated damage signaling and their potential relevance to diabetic skeletal muscle are summarized and exercise is discussed as a modulator of upstream metabolic and inflammatory stress.
Peng-Yu Fu, Yuxuan Shi, Songbo Li et al.
· Health and Metabolism · 0 citations