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Author

Yuyan Zhou

2 papers indexed here

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Open access Sep 2026

Targeting PGAM5-Drp1 axis modulates mitochondrial dynamics and inhibits pancreatic acinar cell necroptosis in severe acute pancreatitis

Severe acute pancreatitis (SAP) is a high-mortality disease characterized by extensive pancreatic necrosis and uncontrolled inflammation. Mitochondrial dysfunction and pancreatic acinar cells (PACs) necroptosis are critical pathological events in SAP, while the role of the mitochondrial protein phosphoglycerate m...

Xiao-Rong Tian, Wei Du, Yu-Yan Zhou et al. · 0 citations
Aug 2026

In situ macrophage reprogramming via micropatch engineering for safe and effective antitumor adoptive cell therapy.

Adoptive cell therapy with macrophages holds great promise for treating solid tumors, but its clinical impact has been limited. The problem is twofold: the immunosuppressive tumor microenvironment quickly silences the anti-tumor activity of transferred cells, and systemic activation strategies often provoke off-target...

Yongkang Xu, Lei Cao, Yuyan Zhou et al. · 0 citations

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