INTEGRATED VIRTUAL SCREENING AND ADMET EVALUATION OF IMIDAZOLE DERIVATIVES TARGETING GSK-3Β AS POTENTIAL ANTICANCER AGENTS
Glycogen Synthase Kinase -3β (GSK-3β) is a multifunctional serine/ threonine protein kinase interfere in the regulation of cell proliferation, apoptosis, metabolism and multiple oncogenic signalling pathways. GSK-3β has been linked with progression of several human malignancies, making it protein target for anticancer...