Design of experiments for the optimization of mefenamic acid microencapsulation in ec/hpmc cellulose derivatives and drug release improvement using β-cyclodextrin inclusion complex
Mefenamic acid (MA) is one of the low water soluble non-steroidal anti inflammatory drugs (NSAID), exhibiting poor wetting and poor dissolution. MA forms with β-cyclodextrin supramolecular inclusion complexes approving a drug solubility enhancement. The aim of the study is to combine the solubilization capability of a...